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What Nucleic Acids ?

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• Nucleic acids are a long chain polymers of nucleotides which are joined

together by means of phosphodiester linkages.

Two types- DNA & RNA

Nucleiotide of DNA and RNA are made up of – Nitrogenous base, sugar and

phosphate.

• In phosphodiester bonds, one phosphoric acid molecule forms bonds with the

3′ carbon of one pentose molecule as well as with the 5′ carbon of a second

pentose molecule.

• Thus each sugar and phosphoric acid forms bonds with two phosphoric acid

and pentose molecules; these linkages generate the sugar-phosphate

backbone of the nucleic acids. The DNA and RNA bases are attached to the 1′

carbon of the pentose residues.

• This assembly of phosphoric acid, pentose and organic base residues is known

as polydeoxyribonucleotide in case of DNA and polyribonucleotide in case of

RNA. Each nucleotide is composed of three distinct molecules : one molecule

each of sugar, phosphoric acid and a nitrogenous base.

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